sodium hydrogencarbonate in methanol

ammonia in methanol Product distribution / selectivity;

ammonia in methanol Product distribution / selectivity;

1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 1.2: Reflux 2.1: tetramethyl-ammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme

1.1: diisobutylaluminium hydride / toluene / -78 °C 2.1: methanesulfonyl chloride; triethylamine / dichloromethane 3.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 3.2: Reflux 4.1: tetramethyl-ammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme

1.1: N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide; lithium hexamethyldisilazane / tetrahydrofuran / -78 °C 2.1: diisobutylaluminium hydride / toluene / -78 °C 3.1: methanesulfonyl chloride; triethylamine / dichloromethane 4.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 4.2: Reflux 5.1: tetramethyl-ammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C 2.1: N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide; lithium hexamethyldisilazane / tetrahydrofuran / -78 °C 3.1: N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide; lithium hexamethyldisilazane / tetrahydrofuran / -78 °C 4.1: diisobutylaluminium hydride / toluene / -78 °C 5.1: methanesulfonyl chloride; triethylamine / dichloromethane 6.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 6.2: Reflux 7.1: tetramethyl-ammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme

N-(N-L-γ-glutamyl-L-cysteinyl)glycine T=37°C; 1 h;

sodium methylate

Multistep reaction;