二氟-羟基-(亚异丙基二氧丙基)-丙酸乙酯合成路线 （共 6 条）
反应条件
1: With iodine; zinc in tetrahydrofuran T=5 - 10°C; 24 h; Ultrasonic irradiation; 2: With water; ammonium chloride
参考文献
PHARMAESSENTIA CORP.
Patent: WO2006/119347 A1, 2006 ;
Location in patent: Page/Page column 9-10 ;
反应条件
morpholine; copper diacetate in toluene 6 h; Heating / reflux;
参考文献
CHEMAGIS LTD.; PERRIGO COMPANY
Patent: WO2007/70804 A2, 2007 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: With 1,1-dibromo ethane; methylsilyl chloride; zinc in tetrahydrofuran T=60°C; 0.5 h; Heating / reflux; 2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
参考文献
WO2008/117955 A1, ;
Page/Page column 22 ;
反应条件
1: With chloro-trimethyl-silane; zinc in tetrahydrofuran 2.5 - 2.66667 h; Heating / reflux; 2: With hydrogenchloride; water in tetrahydrofuran T=0 - 20°C; 0.25 h;
参考文献
WO2007/49295 A2, ;
Page/Page column 12; 15 ;
反应条件
silica gel in hexane; dichloromethane; ethyl acetate Resolution of racemate;
参考文献
US2009/124797 A1, ;
Page/Page column 6 ;
反应条件
2,6-dimethylpyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=33 - 36°C; 3 h;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
