3-(4-溴苯基)-1,4-二氮杂螺[4.4]-2-壬酮合成路线 （共 4 条）
反应条件
H-Y Zeolites in methanol
Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/34061 A1, 2009 ;
Location in patent: Page/Page column 35 ;
WO 2009/034061 A1
反应条件
1: sodium cyanide; 4-bromo-benzaldehyde With ammonium hydroxide; ammonium acetate in ethanol; water
T=20°C; 4 h; Inert atmosphere;
2: cyclopentanone in ethanol; tert-butyl methyl ether; butan-1-ol
T=80°C; 16 h; Inert atmosphere;
参考文献
Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 700 - 706
反应条件
sodium ethanolate in butan-1-ol
T=80°C; 12 h; Large scale reaction;
参考文献
Graham, Jonathan P.; Langlade, Nathalie; Northall, John M.; Roberts, Alastair J.; Whitehead, Andrew J.
Organic Process Research and Development, 2011 , vol. 15, # 1 p. 44 - 48
反应条件
1: ammonium acetate; ammonia / ethanol; water / 4 h / 20 °C / Large scale reaction
2: sodium ethanolate / butan-1-ol / 12 h / 80 °C / Large scale reaction
View Scheme
参考文献
Graham, Jonathan P.; Langlade, Nathalie; Northall, John M.; Roberts, Alastair J.; Whitehead, Andrew J.
Organic Process Research and Development, 2011 , vol. 15, # 1 p. 44 - 48
