2-(乙酰氨基)-3-硝基苯甲酸甲酯合成路线 （共 8 条）
反应条件
1: T=20°C; 1 h; 2: With nitric acid; acetic anhydride; acetic acid in water T=10 - 15°C;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2141150 A1, 2010 ;
Location in patent: Page/Page column 102-103 ;
反应条件
sulfuric acid; nitric acid; acetic anhydride T=0 - 5°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 119 - 124
反应条件
potassium hydroxide Heating;
参考文献
Huang, Shu-Ting; Hsei, I-Jen; Chen, Chinpiao
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 17 p. 6106 - 6119
反应条件
1: 1.) aq. KOH, 2.) HCl, NaNO2, 3.) KI, I2 2: 93 percent / conc. H2SO4 / Heating View Scheme
参考文献
Seno, Kaoru; Hagishita, Sanji; Sato, Tomohiro; Kuriyama, Kaoru
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2012 - 2022
反应条件
potassium carbonate in methanol T=60°C; 1 h;
参考文献
Safonov, Igor G.; Heerding, Dirk A.; Keenan, Richard M.; Price, Alan T.; Erickson-Miller, Connie L.; Hopson, Christopher B.; Levin, Jenna L.; Lord, Kenneth A.; Tapley, Peter M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1212 - 1216
反应条件
1: sodium methoxide / methanol / 20 °C 2: 96 percent / hydrogen / Pd/C / methanol / 3 h View Scheme
参考文献
Safonov, Igor G.; Heerding, Dirk A.; Keenan, Richard M.; Price, Alan T.; Erickson-Miller, Connie L.; Hopson, Christopher B.; Levin, Jenna L.; Lord, Kenneth A.; Tapley, Peter M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1212 - 1216
反应条件
1: aq. KOH / Heating
2: diethyl ether
3: H2 / Pd(OH)2/C / methanol / 760 Torr
4: BH3*pyridine / methanol / 20 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Boes, Michael; Bousquet, Yves; Fazal, Gulrez; Gauthier, Jean; Gillard, James; Goulet, Sylvie; LaPlante, Steven; Poupart, Marc-Andre; Lefebvre, Sylvain; McKercher, Ginette; Pellerin, Charles; Austel, Volkhard; Kukolj, George
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 119 - 124
反应条件
hydrogenchloride; potassium hydroxide; iodine; potassium iodide; sodium nitrite
Yield given. Multistep reaction;
参考文献
Seno, Kaoru; Hagishita, Sanji; Sato, Tomohiro; Kuriyama, Kaoru
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2012 - 2022
