2-(4-氨基苯基)-7-(2-吗啉-4-基-乙氧基)咪唑并[2,1-b]-[1,3]苯并噻唑合成路线 (共 4 条)
反应条件
hydrogen; Raney nickel in tetrahydrofuran; methanol
P=7757.43 Torr; 24 h;
参考文献
AMBIT BIOSCIENCES CORP.; GROSS, Timothy, David; PRASAD, Achampeta, Rathan; CITINENI, Janakiram, Rao
Patent: WO2011/56939 A1, 2011 ;
Location in patent: Page/Page column 81-82 ;
反应条件
1: isopropyl alcohol / 24 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 85 °C
3: ammonium chloride; iron / ethanol / 5 h / Reflux
View Scheme
参考文献
UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II; MAINA, Flavio; DONO, Rosanna; CAMBILLAU, Christian; PICCOLO, Oreste; PASSARELLA, Daniele; COLOMBO, Francesco; BOSCH, Joan; MAIGRET, Bernard; LEROUX, Vincent
Patent: WO2011/36303 A1, 2011 ;
WO 2011/036303 A1
反应条件
1.1: water; hydrogen bromide / 4 h / 105 - 110 °C / Industry scale
1.2: 0.5 h / 20 °C / pH 6.5 - 7 / Industry scale
2.1: sodium hydrogencarbonate / butan-1-ol / 110 - 115 °C / Industry scale
3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 5 h / 90 - 95 °C / Industry scale
4.1: hydrogen / Raney nickel / tetrahydrofuran; methanol / 24 h / 7757.43 Torr / autoclave; Inert atmosphere
View Scheme
参考文献
AMBIT BIOSCIENCES CORP.; GROSS, Timothy, David; PRASAD, Achampeta, Rathan; CITINENI, Janakiram, Rao
Patent: WO2011/56939 A1, 2011 ;
反应条件
1: isopropyl alcohol / 24 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 85 °C
3: ammonium chloride; iron / ethanol / 5 h / Reflux
View Scheme
参考文献
UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II; MAINA, Flavio; DONO, Rosanna; CAMBILLAU, Christian; PICCOLO, Oreste; PASSARELLA, Daniele; COLOMBO, Francesco; BOSCH, Joan; MAIGRET, Bernard; LEROUX, Vincent
Patent: WO2011/36303 A1, 2011 ;
WO 2011/036303 A1