5-溴-N-(4-甲氧基-2-硝基苯基)-2-氨基吡嗪合成路线 （共 5 条）
反应条件
1: With ethanol; acetic acid; zinc in dichloromethane T=0 - 20°C; 0.5 h; 2: With sodium hydrogencarbonate in water pH=8;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
Location in patent: Page/Page column 52 ;
反应条件
nitric acid; acetic acid
T=10 - 40°C;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
Location in patent: Page/Page column 51; 52 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; copper diacetate / dichloromethane / 12 h / 20 °C
2: nitric acid; acetic acid / 10 - 40 °C
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
反应条件
1.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C
2.1: 1 h / 80 °C
2.2: pH 9 - 10
2.3: 3 h / 100 °C
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
反应条件
1.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C
2.1: 1 h / 80 °C
2.2: pH 9 - 10
2.3: 3 h / 100 °C
3.1: copper(I) oxide; ammonia / ethylene glycol / Sealed tube
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
