5-[5-甲氧基-2-三氟甲基-1H-苯并咪唑]-2-氨基吡嗪合成路线 （共 5 条）
反应条件
copper(I) oxide; ammonia in ethylene glycol
T=70°C; 3 h;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
Location in patent: Page/Page column 52; 53 ;
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; copper diacetate / dichloromethane / 12 h / 20 °C
2.1: nitric acid; acetic acid / 10 - 40 °C
3.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C
4.1: 1 h / 80 °C
4.2: pH 9 - 10
4.3: 3 h / 100 °C
5.1: copper(I) oxide; ammonia / ethylene glycol / Sealed tube
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
反应条件
1.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C
2.1: 1 h / 80 °C
2.2: pH 9 - 10
2.3: 3 h / 100 °C
3.1: copper(I) oxide; ammonia / ethylene glycol / Sealed tube
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
反应条件
1.1: 1 h / 80 °C
1.2: pH 9 - 10
1.3: 3 h / 100 °C
2.1: copper(I) oxide; ammonia / ethylene glycol / Sealed tube
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
反应条件
1.1: nitric acid; acetic acid / 10 - 40 °C
2.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C
3.1: 1 h / 80 °C
3.2: pH 9 - 10
3.3: 3 h / 100 °C
4.1: copper(I) oxide; ammonia / ethylene glycol / Sealed tube
View Scheme
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/38775 A1, 2009 ;
