N-甲氧基-n-甲基烟酰胺合成路线 （共 20 条）
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C 1.2: Amberlite IRC-50 / tetrahydrofuran 2.1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C 3.1: 84 percent / ammonium acetate / ethanol View Scheme
参考文献
Kruse, Chris G.; Bouw, Jan P.; Hes, Roelof van; Kuilen, Aalt van de; Hartog, Jack A. J. den
Heterocycles, 1987 , vol. 26, # 12 p. 3141 - 3151
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C 1.2: 77 percent / tetrahydrofuran / -78 - 20 °C 2.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C 2.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C 3.1: 98 percent / CH2Cl2; methanol / 1 h / 20 °C View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
in tetrahydrofuran Substitution;
参考文献
Synlett, , # 7 p. 1091 - 1093
反应条件
Schwartz's reagent in tetrahydrofuran T=20°C; 0.25 h;
参考文献
Spletstoser, Jared T.; White, Jonathan M.; Tunoori, Ashok Rao; Georg, Gunda I.
Journal of the American Chemical Society, 2007 , vol. 129, # 11 p. 3408 - 3419
反应条件
Yield given. Multistep reaction;
参考文献
Basha, Fatima Z.; DeBernardis, John F.
Tetrahedron Letters, 1984 , vol. 25, # 46 p. 5271 - 5274
反应条件
magnesium; copper(I) bromide 1.) THF, 30 deg C, 30 min, 2.) THF, 20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 26, # 12 p. 3141 - 3151
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78 - -40°C; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane T=20 - 100°C; 1 h; Inert atmosphere;
参考文献
Bommegowda, Yadaganahalli K.; Lingaraju, Gejjalagere S.; Thamas, Saji; Vinay Kumar, Koravangala S.; Pradeepa Kumara, Challanayakanahally S.; Rangappa, Kanchugarakoppal S.; Sadashiva, Marilinganadoddi P.
Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2693 - 2695
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=20°C;
参考文献
Cutulic, Sylvain P. Y.; Murphy, John A.; Farwaha, Hardeep; Zhou, Sheng-Ze; Chrystal, Ewan
Synlett, 2008 , # 14 p. 2132 - 2136
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C 1.2: 77 percent / tetrahydrofuran / -78 - 20 °C 2.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C 2.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C 3.1: sodium triacetoxyborohydride; AcOH / CH2Cl2; tetrahydrofuran / -78 - 20 °C 3.2: Amberlyst 15 / CH2Cl2; tetrahydrofuran / 1 h / 20 °C 3.3: 46 percent / Et3N / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
