hydrogenchloride; water in methanol T=20°C; 2 h;

hydrogenchloride; water in methanol 2 h; Inert atmosphere;

1: dichloromethane / 2 h / 20 °C 2: ammonium hydroxide / dichloromethane / 3 h / 0 - 20 °C 3: hydrogenchloride; water / methanol / 2 h / 20 °C View Scheme

1: water; sodium hydroxide / ethanol / 1 h / Reflux 2: dichloromethane / 2 h / 20 °C 3: ammonium hydroxide / dichloromethane / 3 h / 0 - 20 °C 4: hydrogenchloride; water / methanol / 2 h / 20 °C View Scheme

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C 2.1: sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C 2.2: 1 h / -40 °C 3.1: water; sodium hydroxide / ethanol / 1 h / Reflux 4.1: dichloromethane / 2 h / 20 °C 5.1: ammonium hydroxide / dichloromethane / 3 h / 0 - 20 °C 6.1: hydrogenchloride; water / methanol / 2 h / 20 °C View Scheme

1.1: sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C 1.2: 1 h / -40 °C 2.1: water; sodium hydroxide / ethanol / 1 h / Reflux 3.1: dichloromethane / 2 h / 20 °C 4.1: ammonium hydroxide / dichloromethane / 3 h / 0 - 20 °C 5.1: hydrogenchloride; water / methanol / 2 h / 20 °C View Scheme