N-[1,1-二[(乙酰氧基)甲基]-3-(4-溴-2-氯苯基)丙基]乙酰胺合成路线 （共 4 条）
反应条件
1: [1,1-bis(hydroxymethyl)-3-(4-bromo-2-chlorophenyl)propyl]carbamic acid tert-butyl ester With hydrogenchloride in water; ethyl acetate
T=30°C; 1 h;
2: With sodium hydroxide in water
3: acetic anhydride With pyridine
T=20°C; 11 h;
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP2017257 A1, 2009 ;
Location in patent: Page/Page column 24 ;
反应条件
pyridine
T=0 - 20°C;
参考文献
Hamada, Maiko; Nakamura, Mitsuharu; Kiuchi, Masatoshi; Marukawa, Kaoru; Tomatsu, Ayumi; Shimano, Kyoko; Sato, Noriko; Sugahara, Kunio; Asayama, Mahoko; Takagi, Kan; Adachi, Kunitomo
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3154 - 3168
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane
T=120°C; 9 h;
参考文献
Hamada, Maiko; Kiuchi, Masatoshi; Adachi, Kunitomo
Synthesis, 2007 , # 13 p. 1927 - 1929
反应条件
1: 86 percent / Pd2(dba)3*CHCl3; N,N-diisopropylethylamine / tris(dibenzylideneacetone)dipalladium(0) / dioxane / 9 h / 120 °C
2: 97 percent / K2CO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Hamada, Maiko; Kiuchi, Masatoshi; Adachi, Kunitomo
Synthesis, 2007 , # 13 p. 1927 - 1929
