tetrabutylammomium bromide; sodium hydrogencarbonate; potassium bromide in N,N-dimethyl-formamide T=40 - 55°C; 0.75 h; Inert atmosphere;

1: 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 2: 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate With tetraethylammonium bromide T=22 - 25°C;

potassium hydrogencarbonate in acetonitrile T=10 - 15°C;

1: 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate With lithium iodide in acetone T=20°C; 1 h; 2: C7H9NOS With triethylamine in dichloromethane T=20°C; 2.5 h; Product distribution / selectivity;

1: 2,2'-azo-bisisobutyronitrile; acetic acid / ethyl acetate; water 2: tetrabutylammomium bromide; sodium bromide; potassium hydrogencarbonate / ethyl acetate; N,N-dimethyl-formamide; water View Scheme

4-(N,N-dimethlyamino)pyridine in acetonitrile T=22 - 25°C;