2-氧代-2,4,5,6,7a-六氢噻吩并[3,2-c]吡啶盐酸盐合成路线 （共 3 条）
反应条件
triethylamine in methanol; acetone
参考文献
ZENTIVA, K.S.; STEPANKOVA, Hana; KAMINSKA, Katerina; HAJICEK, Josef
Patent: WO2011/57592 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
1: α-cyclopropylcarbonyl-2-fluorobenzyl bromide; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 1.5 h; 2: acetic anhydride With N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 2 h;
参考文献
WO2011/57592 A1, ;
Page/Page column 10; 11 ;
反应条件
1: 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With tetraethylammonium bromide; N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 1.5 h; 2: acetic anhydride With N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 2 h;
参考文献
WO2011/57592 A1, ;
Page/Page column 12; 13 ;
