pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 16 h;

1: With n-butyllithium in diethyl ether; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: With boric acid trimethyl ester in diethyl ether; hexane Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether; hexane

potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=80°C; 16 h;

tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethylene glycol dimethyl ether; water T=85°C; Suzuki coupling; 12 h; Inert atmosphere;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 4 h; Heating;