5-三氟甲基-3-嘧啶甲腈合成路线 (共 3 条)
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 2: With ammonia in diethyl ether; water; N,N-dimethyl-formamide T=20°C;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 84 ;
WO 2009/042694 A1
反应条件
in N,N-dimethyl-formamide T=100°C; 8 h; Sealed tubeInert atmosphere;
参考文献
Organic Letters, , vol. 16, # 6 p. 1744 - 1747
反应条件
1: With sodium tetrahydroborate; cobalt(II) chloride in ethanol T=50°C; 2 h; 2: With hydrogenchloride; water in ethanol T=20°C; pH=1 - 2; 3: With ammonia in ethanol; water pH=9;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 84 ;
WO 2009/042694 A1