4-氯-1H-吡咯并[2,3-b]吡啶-5-羧酸甲酯合成路线 （共 2 条）
反应条件
1: 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
18 h; Inert atmosphere;
2: methanol in dichloromethane
2 h;
参考文献
Helicon Therapeutics, Inc.
Patent: US2012/95016 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1.1: sec.-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
View Scheme
参考文献
BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art
Patent: WO2012/58645 A1, 2012 ;
WO 2012/058645 A1
