吡唑并[1,5-a]吡嗪-2-羧酸, 4,5,6,7-四氢-4-氧代-,乙酯合成路线 （共 2 条）
反应条件
1: With hydrogenchloride in 1,4-dioxane
T=20°C; 1 h; Inert atmosphere;
2: With ammonia in methanol; dichloromethane
参考文献
VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; STAUFFER, Shaun, R.; BARTOLOMÉ-NEBREDA, José Manuel; CONDE-CEIDE, Susana; MACDONALD, Gregor, James; TONG, Han Min; ALCÁZAR-VACA, Manuel Jesús; ANDRÉS-GIL, José Ignacio
Patent: WO2013/192350 A1, 2013 ;
Location in patent: Paragraph 00591 ;
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
View Scheme
参考文献
VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; STAUFFER, Shaun, R.; JONES, Carrie, K.; CONDE-CEIDE, Susana; TONG, Han Min; BARTOLOME-NEBREDA, Jose, Manuel; MACDONALD, Gregor, James
Patent: WO2012/78817 A1, 2012 ;
WO 2012/078817 A1
