4-硝基-2-(三氟甲基)吡啶合成路线 （共 3 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol; water T=20°C; 6 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
1: With sulfuric acid; nitric acid
T=0 - 125°C; 4 h;
2: With sodium hydroxide; water
pH=7;
参考文献
ASTRAZENECA AB
Patent: US2009/170849 A1, 2009 ;
Location in patent: Page/Page column 14 ;
US 20090170849 A1
反应条件
sulfuric acid; nitric acid
T=130°C; 5 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
