1.1: 95 percent / NEt3 / CH2Cl2 / 4 h / -78 - 20 °C 2.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 89 percent / tetrahydrofuran; hexane / 16 h / -78 °C 3.1: NEt3; iodine / methanol / 0.33 h / 20 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 99 percent / NEt₃; DMAP / CH₂Cl₂ / 3 h / 20 &deg;C<br />2: 86 percent / ammonia (g) / CH₂Cl₂ / 18 h / -78 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: Mg / diethyl ether<br />1.2: 69 percent / diethyl ether / 16 h / -78 - 20 &deg;C<br />2.1: 82 percent / hydroxylamine hydrochloride / ethanol; pyridine / 2 h / 60 &deg;C<br />3.1: 99 percent / NEt₃; DMAP / CH₂Cl₂ / 3 h / 20 &deg;C<br />4.1: 86 percent / ammonia (g) / CH₂Cl₂ / 18 h / -78 - 20 &deg;C<br /> <br /> &nbsp;