2-(3-羟基-2-氧代吡啶-1(2H)-基)乙酸乙酯合成路线 （共 5 条）
参考文献
Bristol-Myers Squibb Company
Patent: US6458783 B1, 2002 ;
反应条件
in water; ethyl bromoacetate
参考文献
National Research Development Corp.
Patent: US4585780 A1, 1986 ;
反应条件
24 h; RefluxInert atmosphere;
参考文献
Hanif, Muhammad; Henke, Helena; Meier, Samuel M.; Martic, Sanela; Labib, Mahmoud; Kandioller, Wolfgang; Jakupec, Michael A.; Arion, Vladimir B.; Kraatz, Heinz-Bernhard; Keppler, Bernhard K.; Hartinger, Christian G.
Inorganic Chemistry, 2010 , vol. 49, # 17 p. 7953 - 7963
参考文献
Streater; Taylor; Hider; Porter
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1749 - 1755
反应条件
1: 83 percent / aq. NaOH / 0.33 h
2: dicyclohexylcarbodiimide / tetrahydrofuran / 0 deg C, 20 min; room temperature, 1 h
3: 33 percent / Et3N / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Streater; Taylor; Hider; Porter
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1749 - 1755
