1: 1.) N-methylmorpholine, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / 1.) DMF, room temperature, 20 min, 2.) DMF, room temperature, 18 h 2: 65 percent / hydrogen, glacial acetic acid / Pd on carbon / ethanol; H2O / 18 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 77 percent / 24 h / Heating<br />2: 83 percent / aq. sodium hydroxide / methanol; H₂O / 6 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 13.79 g / 48 h / Heating<br />2: 95 percent / aq. NaOH / methanol; H₂O / 5 h / pH 12 / Heating<br /> <br /> &nbsp;