B-(1-乙基-1H-吲唑-5-基)硼酸合成路线 （共 2 条）
反应条件
1: 5-bromo-1-ethyl-1H-indazole With n-butyllithium in tetrahydrofuran; hexane
T=-60 - -10°C; 1.25 h;
2: tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-60 - 20°C;
3: water With hydrogenchloride in tetrahydrofuran; hexane
1 h;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 80 ;
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
1.2: 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 1.25 h / -60 - -10 °C
2.2: -60 - 20 °C
2.3: 1 h
View Scheme
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
