脱乙酰基2-O-叔-丁基二甲基硅烷基普拉格雷合成路线 （共 6 条）
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in acetonitrile T=-15°C; 1 h;
参考文献
EP2003136 A1, ;
Page/Page column 10 ;
反应条件
acetic acid in acetyl chloride; toluene
反应条件
1: With acetic acid in toluene T=20°C; Inert atmosphere; 2: With sodium hydrogencarbonate in water; toluene Product distribution / selectivity;
参考文献
WO2012/1486 A1, ;
Page/Page column 23 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in acetic anhydride; acetonitrile
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran; ethanol; acetic anhydride
反应条件
1: With hydrogenchloride; water in ethyl acetate T=20°C; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 22 ;
