(3R,4s)-3-羟基-4-苯基吡咯烷-1-羧酸叔丁酯合成路线 （共 8 条）
反应条件
Novozym 435 in tert-butyl methyl ether
T=45°C; 24 h; Resolution of racemateEnzymatic reaction; Temperature; enantioselective reaction;
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
反应条件
BUTE-3 lipase in di-isopropyl ether
T=30°C; 72 h; Resolution of racemateEnzymatic reaction; Solvent; enantioselective reaction;
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
反应条件
copper(l) iodide in tetrahydrofuran
T=0°C;
参考文献
Lin, Peter; Chang, Lehua; DeVita, Robert J.; Young, Jonathan R.; Eid, Ronsar; Tong, Xinchun; Zheng, Song; Ball, Richard G.; Tsou, Nancy N.; Chicchi, Gary G.; Kurtz, Marc M.; Tsao, Kwei-Lan C.; Wheeldon, Alan; Carlson, Emma J.; Eng, WaiSi; Burns, H. Donald; Hargreaves, Richard J.; Mills, Sander G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5191 - 5198
反应条件
Novozym 435 in hexane
T=30°C; 72 h; Resolution of racemateEnzymatic reaction; Solvent; enantioselective reaction;
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
反应条件
1: pyrrolidine / dichloromethane / 0 - 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 98.5 h / 0 - 20 °C
3: copper(l) iodide / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
4: pyridine / 26 h / -10 - 25 °C / |Inert atmosphere
5: Novozym 435 / tert-butyl alcohol; aq. phosphate buffer / 192 h / 20 °C / pH 7 / |Resolution of racemate; |Enzymatic reaction
View Scheme
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 98.5 h / 0 - 20 °C
2: copper(l) iodide / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
3: pyridine / 26 h / -10 - 25 °C / |Inert atmosphere
4: Novozym 435 / tert-butyl alcohol; aq. phosphate buffer / 192 h / 20 °C / pH 7 / |Resolution of racemate; |Enzymatic reaction
View Scheme
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
反应条件
1: copper(l) iodide / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
2: pyridine / 26 h / -10 - 25 °C / |Inert atmosphere
3: Novozym 435 / tert-butyl alcohol; aq. phosphate buffer / 192 h / 20 °C / pH 7 / |Resolution of racemate; |Enzymatic reaction
View Scheme
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
反应条件
BUTE-3 lipase
T=30°C; 72 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
