1-{[(1R,2S,6R)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-3-{[(1S,2R,6S)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-2-丙胺合成路线 （共 3 条）
→
95245-29-71-{[(1R,2S,6R)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-3-{[(1S,2R,6S)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-2-丙胺
反应条件
ammonium acetate; sodium cyanoborohydride in tetrahydrofuran; methanol
T=25°C; 48 h;
参考文献
Holman, Geoffrey D.; Midgley, Peter J. W.
Carbohydrate Research, 1984 , vol. 135, p. 337 - 341
→
95245-29-71-{[(1R,2S,6R)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-3-{[(1S,2R,6S)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-2-丙胺
反应条件
1: 1.) NaH / 1.) DMF, RT, 2.) DMF, a.) RT, overnight, b.) 45 deg C, 4 h
2: 75 percent / aq. NH3, H2 / 50percent Raney nickel / methanol / 48 h / Ambient temperature
View Scheme
参考文献
Sher, Philip M.; Kronenthal, David R.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 21 - 27
→
95245-29-71-{[(1R,2S,6R)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-3-{[(1S,2R,6S)-4,4-二甲基-3,5,10,11-四氧杂三环[6.2.1.02,6]十一烷-7-基]氧基}-2-丙胺
反应条件
1: 50 percent / P2O5 / dimethylformamide; dimethylsulfoxide / 3.5 h / 60 °C
2: 70 percent / NH4OAc, NaBH3CN / methanol; tetrahydrofuran / 48 h / 25 °C
View Scheme
参考文献
Holman, Geoffrey D.; Midgley, Peter J. W.
Carbohydrate Research, 1984 , vol. 135, p. 337 - 341
