4-溴-3-甲基-1,2-苯二胺合成路线 （共 3 条）
反应条件
1.1: dichloromethane / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: potassium carbonate / methanol / 50 °C
3.1: tin(ll) chloride / ethanol / 4 h / 70 °C
3.2: pH > 7
View Scheme
参考文献
ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;
反应条件
1.1: potassium carbonate / methanol / 50 °C
2.1: tin(ll) chloride / ethanol / 4 h / 70 °C
2.2: pH > 7
View Scheme
参考文献
ABBOTT LABORATORIES; KRUEGER, Allan, C.; KATI, Warren, M.; CARROLL, William, A.; PRATT, John, K.; HUTCHINSON, Douglas, K.
Patent: WO2012/83170 A1, 2012 ;
反应条件
1: sulfuric acid; nitric acid / 0 - 20 °C
2: SnCl2·2H2O / ethanol; ethyl acetate / 12 h / 80 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1
