2-叔丁基-6-氟-5-硝基-1H-吲哚合成路线 （共 4 条）
反应条件
tetrabutyl ammonium fluoride in N,N-dimethyl-formamide
T=100°C;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 113 ;
反应条件
1: bromine / chloroform; acetic acid
2: CuI; triethylamine / Pd(PPh3)2Cl2 / water; toluene
3: triethylamine / dichloromethane
4: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: CuI; triethylamine / Pd(PPh3)2Cl2 / water; toluene
2: triethylamine / dichloromethane
3: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: triethylamine / dichloromethane
2: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
