2-叔丁基-7-氟-5-硝基-1H-吲哚合成路线 （共 5 条）
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=20 - 120°C;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: bromine / acetic acid
2: CuI / Pd(PPh3)2Cl2 / triethylamine
3: pyridine / dichloromethane
4: potassium tert-butylate / water; N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: CuI / Pd(PPh3)2Cl2 / triethylamine
2: pyridine / dichloromethane
3: potassium tert-butylate / water; N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: CuI / Pd(PPh3)2Cl2 / triethylamine
2: pyridine / dichloromethane
3: potassium tert-butylate / water; N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: pyridine / dichloromethane
2: potassium tert-butylate / water; N,N-dimethyl-formamide
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
