2-叔丁基-5-硝基-1H-吲哚-7-羧酸甲酯合成路线 （共 6 条）
反应条件
thionyl chloride in methanol; ethyl acetate; Petroleum ether
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
thionyl chloride
T=0 - 80°C; 12 h;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 126 ;
反应条件
1: CuI / Pd(PPh3)2Cl2 / ethyl acetate; triethylamine; Petroleum ether
2: tetrabutyl ammonium fluoride / tetrahydrofuran; water
3: KOH / ethanol; ethyl acetate; Petroleum ether
4: thionyl chloride / methanol; ethyl acetate; Petroleum ether
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: CuI / Pd(PPh3)2Cl2 / ethyl acetate; triethylamine; Petroleum ether
2: tetrabutyl ammonium fluoride / tetrahydrofuran; water
3: KOH / ethanol; ethyl acetate; Petroleum ether
4: thionyl chloride / methanol; ethyl acetate; Petroleum ether
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran; water
2: KOH / ethanol; ethyl acetate; Petroleum ether
3: thionyl chloride / methanol; ethyl acetate; Petroleum ether
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: KOH / ethanol; ethyl acetate; Petroleum ether
2: thionyl chloride / methanol; ethyl acetate; Petroleum ether
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
