in water; trifluoroacetic acid T=20°C; 6 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3556712', constants.ctx, '0')">potassium <i>tert</i>-butylate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=-78&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 83 percent / MeSO₂Cl, Et₃N / benzene / 12 h / 20 &deg;C<br />2: 2) t-BuOK / 1) THF, 0 deg C, 0.25 h; THF, -78 deg C, 0.5 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) butyl-lithium, di-isopropylamine, dimethyl sulphide, copper(I) bromide, 2.) aq. copper (II) acetate / 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, 2 h<br />2: trifluoroacetic anhydride, pyridine / CH₂Cl₂ / 1 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) aq. sodium hydroxide / 1.) 20 deg C, 2 d, 2.) acetone, reflux, 6 h<br />2: trifluoroacetic anhydride, pyridine / CH₂Cl₂ / 1 h<br /> <br /> &nbsp;