6-溴-2-氯-8-氟喹唑啉合成路线 （共 3 条）
反应条件
trichlorophosphate
5 h; Reflux;
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
Location in patent: Page/Page column 77; 79 ;
反应条件
1: N-bromosuccinmide / dichloromethane / 2 h / 20 °C
2: borane-THF / tetrahydrofuran / 0 - 20 °C
3: manganese(IV) oxide / dichloromethane / 20 °C
4: 2 h / 180 °C
5: trichlorophosphate / 5 h / |Reflux
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: borane-THF / tetrahydrofuran / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 20 °C
3: 2 h / 180 °C
4: trichlorophosphate / 5 h / |Reflux
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
