6-溴-2-氯-7-甲氧基-喹唑啉合成路线 （共 4 条）
反应条件
1: borane-THF / tetrahydrofuran / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 20 °C
3: N-bromosuccinmide / dichloromethane
4: neat (no solvent) / 2 h / 180 °C
5: trichlorophosphate / 5 h / 130 °C
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: manganese(IV) oxide / dichloromethane / 20 °C
2: N-bromosuccinmide / dichloromethane
3: neat (no solvent) / 2 h / 180 °C
4: trichlorophosphate / 5 h / 130 °C
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: N-bromosuccinmide / dichloromethane
2: neat (no solvent) / 2 h / 180 °C
3: trichlorophosphate / 5 h / 130 °C
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: neat (no solvent) / 2 h / 180 °C
2: trichlorophosphate / 5 h / 130 °C
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
