1-(4-羟基苄基)咪唑-2-硫醇合成路线 （共 4 条）
反应条件
1: sodium borohydride / ethanol / 24 h / Ambient temperature
2: 12 N HCl / ethanol; H2O / 2 h / Heating
3: BBr3 / CH2Cl2 / 1.5 h
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 0.33 h / Heating
2: sodium borohydride / ethanol / 24 h / Ambient temperature
3: 12 N HCl / ethanol; H2O / 2 h / Heating
4: BBr3 / CH2Cl2 / 1.5 h
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
boron tribromide in dichloromethane
Yield given;
参考文献
Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Frazee, James S.; Erickson, Robert W.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 887 - 889
反应条件
1: 12 N HCl / ethanol; H2O / 2 h / Heating
2: BBr3 / CH2Cl2 / 1.5 h
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
