3-(3,5-二氯苯基)丙酸合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2585.7 Torr; 5 h;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
water in acetonitrile T=120°C; 0.5 h; microwave irradiation;
参考文献
Sharma, Anil K.; Subramani, Amutha V.; Gorman, Christopher B.
Tetrahedron, 2007 , vol. 63, # 2 p. 389 - 395
反应条件
palladium monocarbide in tetrahydrofuran
反应条件
1: 71 percent / triethylammonium formate 2: 100 percent / H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation View Scheme
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
chlorosulfonic acid T=0°C; Friedel-Crafts reaction; 1 h;
参考文献
Sharma, Anil K.; Subramani, Amutha V.; Gorman, Christopher B.
Tetrahedron, 2007 , vol. 63, # 2 p. 389 - 395
反应条件
1: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
2: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
