4-(2,5-二甲基-1H-吡咯-1-基)苯甲醛合成路线 （共 8 条）
反应条件
n-butyllithium in diethyl ether; hexane 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h;
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 96 percent / AcOH / benzene / 4 h / Heating 2: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2801 - 2807
反应条件
1: 96 percent / AcOH / benzene / 4 h / Heating 2: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2801 - 2807
反应条件
1: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 2: HgCl2 / methanol; H2O / 4 h / Heating 3: KOH / methanol / 2 h / Heating 4: H2NOH*HCl / ethanol; H2O / 24 h / Heating 5: H2SO4 / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 2: HgCl2 / methanol; H2O / 4 h / Heating 3: KOH / methanol / 2 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 2: HgCl2 / methanol; H2O / 4 h / Heating 3: KOH / methanol / 2 h / Heating 4: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 5: H2NOH*HCl / ethanol; H2O / 24 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 2: HgCl2 / methanol; H2O / 4 h / Heating 3: KOH / methanol / 2 h / Heating 4: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 5: H2NOH*HCl / ethanol; H2O / 24 h / Heating 6: H2SO4 / ethanol / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 2: HgCl2 / methanol; H2O / 4 h / Heating 3: KOH / methanol / 2 h / Heating 4: H2NOH*HCl / ethanol; H2O / 24 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
