反应条件
1: 2-bromo-2-methyl-butyric acid With oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide
T=20°C; 2 h;
2: ethanol With N-ethyl-N,N-diisopropylamine
T=20°C; 20 h;
参考文献
Johansson, Lars; Fotsch, Christopher; Bartberger, Michael D.; Castro, Victor M.; Chen, Michelle; Emery, Maurice; Gustafsson, Sonja; Hale, Clarence; Hickman, Dean; Homan, Evert; Jordan, Steven R.; Komorowski, Renee; Li, Aiwen; McRae, Kenneth; Moniz, George; Matsumoto, Guy; Orihuela, Carlos; Palm, Gunnar; Veniant, Murielle; Wang, Minghan; Williams, Meredith; Zhang, Jiandong
Journal of Medicinal Chemistry, 2008 , vol. 51, # 10 p. 2933 - 2943