5-溴-3-(苯基乙炔)吡啶-2-胺合成路线 （共 4 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in N,N-dimethyl-formamide
T=110°C; Sonogashira coupling; 2 h;
参考文献
Majumdar; Mondal
Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6951 - 6953
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine in tetrahydrofuran
T=20°C; Sonogashira Cross-Coupling; Inert atmosphere;
参考文献
Leboho, Tlabo C.; Van Vuuren, Sandy F.; Michael, Joseph P.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 2 p. 307 - 315
反应条件
1: 95 percent / NBS / dimethylsulfoxide; H2O / 1 h / 0 °C
2: 73 percent / Pd(PPh3)2Cl2; CuI; Et3N / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Majumdar; Mondal
Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6951 - 6953
反应条件
1: iodine; KIO3; sulfuric acid; acetic acid / water / 8 h / 80 °C
2: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 20 °C / |Inert atmosphere
View Scheme
参考文献
Leboho, Tlabo C.; Van Vuuren, Sandy F.; Michael, Joseph P.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 2 p. 307 - 315
