1-(2-喹啉基)-9H-吡啶并(3,4-b)吲哚合成路线 （共 28 条）
反应条件
in quinoline
1 h; Heating;
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
pyridine hydrochloride
T=210°C; 0.25 h;
参考文献
Rocca; Marsais; Godard; Queguiner
Tetrahedron, 1993 , vol. 49, # 16 p. 3325 - 3342
反应条件
1: 23 percent / LDA/n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2: 38 percent / hydroxylamine/NaOAc / toluene / 48 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
1: T=155°C; 2 h;
2: With palladium 10 on activated carbon
22 h; Reflux;
参考文献
He, Liang; Liao, Si-Yan; Tan, Cai-Ping; Ye, Rui-Rong; Xu, Yu-Wen; Zhao, Meng; Ji, Liang-Nian; Mao, Zong-Wan
Chemistry - A European Journal, 2013 , vol. 19, # 36 p. 12152 - 12160
反应条件
tetrakis(triphenylphosphine) palladium(0); zinc(II) chloride in tetrahydrofuran
22 h; Heating;
参考文献
Bracher, Franz; Hildebrand, Dirk
Tetrahedron, 1994 , vol. 50, # 43 p. 12329 - 12336
反应条件
1: 48 percent / EtNO2, 34percent HBF4
2: 1) (i-Pr)2NLi, 2) I2 / 1) THF, hexane, -75 deg C, 4 h, 2) THF, -75 deg C, 1 h
3: 1) K2CO3 / 2) Pd(PPh3)4 / 1) EtOH, toluene, 0.5 h, 2) reflux, 48 h
4: 78 percent / Pd(PPh3)4 / toluene / 60 h / Heating
5: 83 percent / pyridinium chloride / 0.25 h / 210 °C
View Scheme
参考文献
Rocca; Marsais; Godard; Queguiner
Tetrahedron, 1993 , vol. 49, # 16 p. 3325 - 3342
反应条件
1: 1) (i-Pr)2NLi, 2) I2 / 1) THF, hexane, -75 deg C, 4 h, 2) THF, -75 deg C, 1 h
2: 1) K2CO3 / 2) Pd(PPh3)4 / 1) EtOH, toluene, 0.5 h, 2) reflux, 48 h
3: 78 percent / Pd(PPh3)4 / toluene / 60 h / Heating
4: 83 percent / pyridinium chloride / 0.25 h / 210 °C
View Scheme
参考文献
Rocca; Marsais; Godard; Queguiner
Tetrahedron, 1993 , vol. 49, # 16 p. 3325 - 3342
反应条件
1: 1) K2CO3 / 2) Pd(PPh3)4 / 1) EtOH, toluene, 0.5 h, 2) reflux, 48 h
2: 78 percent / Pd(PPh3)4 / toluene / 60 h / Heating
3: 83 percent / pyridinium chloride / 0.25 h / 210 °C
View Scheme
参考文献
Rocca; Marsais; Godard; Queguiner
Tetrahedron, 1993 , vol. 49, # 16 p. 3325 - 3342
反应条件
1: 78 percent / Pd(PPh3)4 / toluene / 60 h / Heating
2: 83 percent / pyridinium chloride / 0.25 h / 210 °C
View Scheme
参考文献
Rocca; Marsais; Godard; Queguiner
Tetrahedron, 1993 , vol. 49, # 16 p. 3325 - 3342
反应条件
hydroxylamine; sodium acetate in toluene
48 h; Heating;
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
