1-(2-喹啉基)-9H-吡啶并(3,4-b)吲哚合成路线 （共 28 条）
反应条件
1: benzene / 14 h / Heating
2: H2 / 5percent Pd-C / xylene / Heating
3: NaOH / H2O; ethanol / 2 h / Heating
4: 98 percent / quinoline / 1 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
N-benzyl-trimethylammonium hydroxide in tetrahydrofuran; methanol
2 h; Heating;
参考文献
Bracher, Franz; Hildebrand, Dirk
Liebigs Annalen der Chemie, 1993 , # 8 p. 837 - 840
反应条件
1: 2.) conc. HCl / 1.) PdCl2(Ph3P)2 / 1.) toluene, reflux, 17 h, 2.) H2O, r.t., 2 h
2: 49 percent / Triton B / methanol; tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Bracher, Franz; Hildebrand, Dirk
Liebigs Annalen der Chemie, 1993 , # 8 p. 837 - 840
反应条件
1: LiOH / tetrahydrofuran; H2O / Ambient temperature
2: 53 percent / copper/quinoline / 260 °C
View Scheme
参考文献
Molina, Pedro; Fresneda, Pilar M.; Garcia-Zafra, Sagrario; Almendros, Pedro
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8851 - 8854
反应条件
1: 88 percent / POBr3 / various solvent(s) / 4 h / 120 °C
2: potassium hydride (35 percent in oil), tert.-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C
3: 53 percent / ZnCl2, Pd(Ph3P)4 / tetrahydrofuran / 22 h / Heating
View Scheme
参考文献
Bracher, Franz; Hildebrand, Dirk
Tetrahedron, 1994 , vol. 50, # 43 p. 12329 - 12336
反应条件
3: 65 percent / toluene / 160 °C
4: 99 percent / HCOOH / Heating
5: LiOH / tetrahydrofuran; H2O / Ambient temperature
6: 53 percent / copper/quinoline / 260 °C
View Scheme
参考文献
Molina, Pedro; Fresneda, Pilar M.; Garcia-Zafra, Sagrario; Almendros, Pedro
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8851 - 8854
反应条件
2: 65 percent / toluene / 160 °C
3: 99 percent / HCOOH / Heating
4: LiOH / tetrahydrofuran; H2O / Ambient temperature
5: 53 percent / copper/quinoline / 260 °C
View Scheme
参考文献
Molina, Pedro; Fresneda, Pilar M.; Garcia-Zafra, Sagrario; Almendros, Pedro
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8851 - 8854
反应条件
1: 65 percent / toluene / 160 °C
2: 99 percent / HCOOH / Heating
3: LiOH / tetrahydrofuran; H2O / Ambient temperature
4: 53 percent / copper/quinoline / 260 °C
View Scheme
参考文献
Molina, Pedro; Fresneda, Pilar M.; Garcia-Zafra, Sagrario; Almendros, Pedro
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8851 - 8854
反应条件
1: potassium hydride (35 percent in oil), tert.-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C
2: 53 percent / ZnCl2, Pd(Ph3P)4 / tetrahydrofuran / 22 h / Heating
View Scheme
参考文献
Bracher, Franz; Hildebrand, Dirk
Tetrahedron, 1994 , vol. 50, # 43 p. 12329 - 12336
反应条件
1: 99 percent / HCOOH / Heating
2: LiOH / tetrahydrofuran; H2O / Ambient temperature
3: 53 percent / copper/quinoline / 260 °C
View Scheme
参考文献
Molina, Pedro; Fresneda, Pilar M.; Garcia-Zafra, Sagrario; Almendros, Pedro
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8851 - 8854
