1-(2-喹啉基)-9H-吡啶并(3,4-b)吲哚合成路线 （共 28 条）
反应条件
1: 87 percent / NaH / dimethylsulfoxide / 1 h / 60 °C
2: 49 percent / n-BuLi / tetrahydrofuran; hexane / 10 h / Ambient temperature
3: 23 percent / LDA/N-BuLi / tetrahydrofuran; hexane / 10 h / -78 °C
4: 35 percent / hydroxylamine hydrochloride/NaOAc / 1,2-dichloro-benzene / 14 h / Heating
5: NaOH / H2O; ethanol / 2 h / Heating
6: 98 percent / quinoline / 1 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
1: 49 percent / n-BuLi / tetrahydrofuran; hexane / 10 h / Ambient temperature
2: 23 percent / LDA/N-BuLi / tetrahydrofuran; hexane / 10 h / -78 °C
3: 35 percent / hydroxylamine hydrochloride/NaOAc / 1,2-dichloro-benzene / 14 h / Heating
4: NaOH / H2O; ethanol / 2 h / Heating
5: 98 percent / quinoline / 1 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
1: 23 percent / LDA/n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2: 38 percent / hydroxylamine/NaOAc / toluene / 48 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
1: 23 percent / LDA/N-BuLi / tetrahydrofuran; hexane / 10 h / -78 °C
2: 35 percent / hydroxylamine hydrochloride/NaOAc / 1,2-dichloro-benzene / 14 h / Heating
3: NaOH / H2O; ethanol / 2 h / Heating
4: 98 percent / quinoline / 1 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
1: 35 percent / hydroxylamine hydrochloride/NaOAc / 1,2-dichloro-benzene / 14 h / Heating
2: NaOH / H2O; ethanol / 2 h / Heating
3: 98 percent / quinoline / 1 h / Heating
View Scheme
参考文献
Hibino; Sugino; Yamochi; Kuwata; Hashimoto; Sato; Amanuma; Karasawa
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 6 p. 2261 - 2265
反应条件
1: magnesium sulfate / dichloromethane / 1 h / |Reflux
2: iodine / tetrahydrofuran / 10 h / |Reflux
3: lithium hydroxide monohydrate / water; acetonitrile / 4 h / 20 °C
4: copper / quinoline / 1 h / 260 °C
View Scheme
参考文献
Ramesh, Subburethinam; Nagarajan, Rajagopal
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 545 - 558
反应条件
1: magnesium sulfate / dichloromethane / 1 h / |Reflux
2: iodine / tetrahydrofuran / 10 h / |Reflux
3: lithium hydroxide monohydrate / water; acetonitrile / 4 h / 20 °C
4: copper / quinoline / 1 h / 260 °C
View Scheme
参考文献
Ramesh, Subburethinam; Nagarajan, Rajagopal
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 545 - 558
反应条件
palladium
T=180 - 200°C; 1 h;
参考文献
Tulyaganov, T. S.; Yunusov, S. Yu.
Chemistry of Natural Compounds, 1990 , vol. 26, # 1 p. 49 - 53
Khimiya Prirodnykh Soedinenii, 1990 , # 1 p. 61 - 67
