1-[[2-(4-氯苯基)乙基]氨基]-2-氯丙烷盐酸盐合成路线 （共 4 条）
反应条件
thionyl chloride; N,N-dimethyl acetamide in toluene T=40 - 62°C; 3 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2008/70111 A2, 2008 ;
Location in patent: Page/Page column 22-23 ;
WO 2008/070111 A2
反应条件
thionyl chloride; N,N-dimethyl acetamide in toluene T=50 - 65°C; 2.5 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2008/70111 A2, 2008 ;
Location in patent: Page/Page column 20-21 ;
WO 2008/070111 A2
反应条件
1: With AlCl3, aluminium chloride in 1,2-dichloro-benzene T=125 - 130°C; 14 - 18 h; 2: With water in 1,2-dichloro-benzene T=60°C; 3: With sodium hydroxide in cyclohexane; water T=20°C; pH=>= 13; 1 h;
参考文献
ARENA PHARMACEUTICALS, INC.; BLACKBURN, Anthony C.; BETTS, William Lucas III; RUETER, Jaimie Karyn; SHAN, Yun; SHIFRINA, Anna; STIRN, Scott
Patent: WO2012/30938 A1, 2012 ;
Location in patent: Page/Page column 83-84 ;
反应条件
1: With AlCl3, aluminium chloride T=126°C; Friedel Crafts; 16 h; Industry scaleInert atmosphere; 2: With sodium hydroxide in cyclohexane; water pH=12; Industry scale; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.; BLACKBURN, Anthony, C.; STIRN, Scott; SHAN, Yun; SHIFRINA, Anna
Patent: WO2012/30951 A1, 2012 ;
Location in patent: Page/Page column 86-87 ;
WO 2012/030951 A1
