N-(5-溴戊基)邻苯二甲酰亚胺合成路线 （共 34 条）
反应条件
1: 90 percent / dimethylformamide / 16 h / 20 °C 2: K2CO3; MeOH / 20 °C 3: PPh3; CBr4 / acetonitrile / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 19 p. 3175 - 3186
反应条件
1: toluene / 3 h / Heating 2: 64.7 g / PBr3 / toluene / 1.5 h / 100 °C View Scheme
参考文献
Synthetic Communications, , vol. 15, # 14 p. 1277 - 1290
反应条件
1: toluene / 3 h / Heating 2: 64.7 g / PBr3 / toluene / 1.5 h / 100 °C View Scheme
参考文献
Synthetic Communications, , vol. 15, # 14 p. 1277 - 1290
参考文献
Budzikiewicz, Herbert; Vieth, Peter-Eric; Krueger, Uwe
Monatshefte fuer Chemie, 1981 , vol. 112, p. 825 - 840
反应条件
1: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 100 deg C, 8 h 2: 1.) hydrazine hydrate, 2.) 4 N aq. HCl / 1.) EtOH, reflux, 8 h, 2.) EtOH, reflux, 6 h View Scheme
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
反应条件
1: 35 percent / K2CO3; NaI / ethanol / Heating 2: 81 percent / NH2NH2 / ethanol; H2O / Heating View Scheme
参考文献
Choi, Ja Youn; Seo, Han Na; Lee, Min Joo; Park, Seong Jun; Park, Sung Jun; Jeon, Ji Young; Kang, Joo Hi; Pae, Ae Nim; Rhim, Hyewhon; Lee, Jae Yeol
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 471 - 475
反应条件
1: ethanol 2: hydrazine hydrate; ethanol / Erwaermen des Reaktionsprodukts mit wss. Salzsaeure 3: pyridine 4: sodium sulfide nonahydrate; ethanol View Scheme
参考文献
May and Baker Ltd.
Patent: US2830008 , 1956 ;
反应条件
1: 40 percent / K2CO3 / dimethylformamide / 48 h 2: 85 percent / conc. HCl / acetic acid; H2O / 10 h / 100 °C 3: dimethylformamide / 10 h / 110 °C View Scheme
参考文献
Constant; Carden; Lhomme
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1035 - 1040
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=80°C; Alkylation;
参考文献
Forbes, Ian T; Cooper, David G.; Dodds, Emma K.; Hickey, Deirdre M.B.; Ife, Robert J.; Meeson, Malcolm; Stockley, Martin; Berkhout, Theo A.; Gohil, Jayneeta; Groot, Pieter H.E.; Moores, Kitty
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1803 - 1806
参考文献
Putochin
Chemische Berichte, 1926 , vol. 59, p. 627
Chem. Zentralbl., 1928 , vol. 99, # I p. 318
