N-(5-溴戊基)邻苯二甲酰亚胺合成路线 （共 34 条）
反应条件
1: With sodium sulfite in water; ethyl acetate
T=95°C; 20 h;
2: With hydrogenchloride in water
T=110°C; 18 h;
参考文献
Deng, Hong; Liu, Xin; Xie, Jie; Yin, Rong; Huang, Naiyan; Gu, Ying; Zhao, Jingquan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1910 - 1919
反应条件
1: 85 percent / K2CO3 / acetonitrile / 24 h / Heating
2: H2 / Pd/C / toluene / 48 h / normal pressure
View Scheme
参考文献
May and Baker Ltd.
Patent: US2830008 , 1956 ;
反应条件
1: 36 percent / tetrahydrofuran / -65 - 0 °C
2: 38 percent / LDA / tetrahydrofuran
View Scheme
参考文献
Naruto, Shunsuke; Shimakawa, Keiko; Mizuta, Hiroyuki; Uno, Hitoshi; Nishimura, Haruki
Heterocycles, 1981 , vol. 16, # 7 p. 1089 - 1092
反应条件
1: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 100 deg C, 8 h
2: 1.) hydrazine hydrate, 2.) 4 N aq. HCl / 1.) EtOH, reflux, 8 h, 2.) EtOH, reflux, 6 h
View Scheme
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
反应条件
triethylamine
T=150°C; 6 h;
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 22 percent / aq. acetic acid
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 88 percent / CHCl3 / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 90 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 94 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 91 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
