N-(5-溴戊基)邻苯二甲酰亚胺合成路线 （共 34 条）
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 92 percent / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 96 percent / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 88 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 89 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 73 percent / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 1.) NaH / 1.) toluene, reflux, 5 h, 2.) toluene, reflux, 15 h
2: hydrazine monohydrate / methanol / 15 h / Heating
View Scheme
参考文献
Tsuchida, Eishun; Nishide, Hiroyuki; Sato, Yoshinori; Kaneda, Manabu
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 6 p. 1890 - 1895
