lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; 2 h;

1.1: 79 percent / LiOH*H2O; aq. H2O2 / tetrahydrofuran / 2 h / 20 °C 2.1: 93 percent / Et3N; pivaloyl chloride; DMAP / tetrahydrofuran / 24 h / Heating 3.1: sodium hexamethyldisilamide / tetrahydrofuran; toluene / 1 h / -78 °C 3.2: 83 percent / tetrahydrofuran; toluene / 3.5 h / -78 °C 4.1: 83 percent / NaBH4 / tetrahydrofuran; H2O / 5 h / 20 °C View Scheme