4-疏基-2-甲氧基苯甲酸合成路线 （共 13 条）
反应条件
1: 79 percent / KI, K2CO3 / tetrabutylammonium chloride / acetone / 4 h / Heating 2: 1.) NaH / 1.) DMF, 2.) DMF, RT, 2.5 h 3: 39.73 g / H2 / 5percent Pd/C / tetrahydrofuran / 1810.02 Torr 4: 1.) NaH / 1.) DMF, 2.) DMF, RT, overnight 5: 1 h / 235 - 245 °C 6: 5 N aq. NaOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 717 - 727
反应条件
1: 39.73 g / H2 / 5percent Pd/C / tetrahydrofuran / 1810.02 Torr 2: 1.) NaH / 1.) DMF, 2.) DMF, RT, overnight 3: 1 h / 235 - 245 °C 4: 5 N aq. NaOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 717 - 727
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF, RT, 2.5 h 2: 39.73 g / H2 / 5percent Pd/C / tetrahydrofuran / 1810.02 Torr 3: 1.) NaH / 1.) DMF, 2.) DMF, RT, overnight 4: 1 h / 235 - 245 °C 5: 5 N aq. NaOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 717 - 727
反应条件
sodium hydroxide T=235°C;
参考文献
Tetrahedron Letters, , vol. 32, # 31 p. 3891 - 3894
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF, RT, overnight 2: 1 h / 235 - 245 °C 3: 5 N aq. NaOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 717 - 727
反应条件
sodium hydroxide in methanol Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 717 - 727
反应条件
1: SOCl2 2: NEt3, DMAP / dimethylformamide 3: 1.) NaH / 1.) DMF 4: DOWEX 50X2 / methanol 5: 1.) NaH / 1.) DMF 6: aq. NaOH / 235 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 31 p. 3891 - 3894
反应条件
1: 1.) NaH / 1.) DMF 2: DOWEX 50X2 / methanol 3: 1.) NaH / 1.) DMF 4: aq. NaOH / 235 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 31 p. 3891 - 3894
反应条件
hydrogenchloride; tin
参考文献
Journal of the Chemical Society, , p. 1375,1379
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, , vol. 3/2, p. 155
反应条件
1: Et3N / acetone / 2 h / Ambient temperature 2: 1.) Et3N, diphenylphosphoryl azide (DPPA) / 1.) MeCN, reflux, 1 h, 2.) MeCN, reflux, 1 h View Scheme
参考文献
Komeshima; Osawa; Nishitoba; Jinno; Kiriu
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 351 - 356
