(4S)-(+)-2,2-二甲基-1,3-二氧戊环-4- 乙酸甲酯合成路线 （共 18 条）
反应条件
ammonia in water 24 h; Ambient temperature;
参考文献
Critcher, Douglas J.; Pattenden, Gerald
Tetrahedron Letters, 1996 , vol. 37, # 50 p. 9107 - 9110
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 5 h;
参考文献
Tursun, Ahmatjan; Canet, Isabelle; Aboab, Bettina; Sinibaldi, Marie-Eve
Tetrahedron Letters, 2005 , vol. 46, # 13 p. 2291 - 2294
反应条件
diisobutylaluminium hydride T=-78°C; Inert atmosphere;
参考文献
Liu, Kai; Arico, Joseph W.; Taylor, Richard E.
Journal of Organic Chemistry, 2010 , vol. 75, # 12 p. 3953 - 3957
反应条件
1: 78.3 percent / diisobutylaluminium hydride / diethyl ether; toluene / 0.25 h / -70 °C 2: 47.6 percent / SnCl2 / CH2Cl2 / 2 h / 20 °C 3: H2 / Ru[(R)-BINAP]Cl2 / methanol / 1.33 h / 20 °C / 37503 Torr View Scheme
参考文献
Tararov, Vitali I.; Koenig, Gerd; Boerner, Armin
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 18 p. 2633 - 2644
反应条件
toluene-4-sulfonic acid
1 h; Ambient temperature;
参考文献
Thiam; Slassi; Chastrette; Amouroux
Synthetic Communications, 1992 , vol. 22, # 1 p. 83 - 95
反应条件
1: With sodium tetrahydroborate; dimethylsulfide borane complex in tetrahydrofuran
T=20°C; 3 h;
2: With methanol in tetrahydrofuran
T=20°C;
3: With sodium carbonate; 2,2-dimethoxy-propane; acetone; toluene-4-sulfonic acid
more than 3 stages;
参考文献
RATIOPHARM GMBH
Patent: WO2005/47276 A2, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
toluene-4-sulfonic acid in acetone
T=20°C; 14 h;
参考文献
Bode, Moira L.; Gates, Paul J.; Gebretnsae, Samson Y.; Vleggaar, Robert
Tetrahedron, 2010 , vol. 66, # 11 p. 2026 - 2036
反应条件
1: dimethyl (S) 2-hydroxybutane-1,4-dioate With sodium tetrahydroborate; dimethylsulfide borane complex in tetrahydrofuran
T=20°C; 3 h;
2: With methanol in tetrahydrofuran
T=20°C;
3: 2,2-dimethoxy-propane; acetone With toluene-4-sulfonic acid
T=20°C;
参考文献
RATIOPHARM GMBH
Patent: WO2006/122644 A2, 2006 ;
Location in patent: Page/Page column 24-25 ;
反应条件
pyridinium p-toluenesulfonate in acetone
2.5 h; Ambient temperature;
参考文献
Mosset, P.; Pointeau, P.; Aubert, F.; Lellouche, J. P.; Beaucourt, J. P.; Gree, R.
Bulletin de la Societe Chimique de France, 1990 , # 2 p. 298 - 315
反应条件
toluene-4-sulfonic acid
T=20°C; 48 h;
参考文献
Dardonville, Christophe; Gilbert, Ian H
Organic and biomolecular chemistry, 2003 , vol. 1, # 3 p. 552 - 559
