3-(4-溴苯基)-5-甲基-4-异噁唑羧酸乙酯合成路线 （共 4 条）
反应条件
sodium methylate in methanol
T=0 - 25°C; 0.666667 h;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0484 ;
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 15 - 20 °C
2: sodium methylate / methanol / 0.67 h / 0 - 25 °C
View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
1: sodium hydroxide; hydroxylamine hydrochloride / ethanol / 2 h / 30 °C
2: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 15 - 20 °C
3: sodium methylate / methanol / 0.67 h / 0 - 25 °C
View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
1: With water; sodium hydroxide in tetrahydrofuran
T=20°C; 3 h;
2: With hydrogenchloride in water
pH=Ca. 3; Cooling with ice;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0485 ;
