4,4,4-三氟-3-三氟甲基丁胺合成路线 （共 3 条）
反应条件
1: hydrogen / Pd/C
2: lithium aluminum hydride / diethyl ether / 0.5 h / Heating
3: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature
4: hydrazine monohydrate / ethanol / 1 h / Heating
View Scheme
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297
反应条件
1: lithium aluminum hydride / diethyl ether / 0.5 h / Heating
2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature
3: hydrazine monohydrate / ethanol / 1 h / Heating
View Scheme
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297
反应条件
1: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature
2: hydrazine monohydrate / ethanol / 1 h / Heating
View Scheme
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297
