pyridinium chlorochromate in dichloromethane T=20°C; 4 h; Molecular sieve;

1: 3-fluoro-benzaldehyde oxime With pyridine; N-chloro-succinimide in tetrahydrofuran T=60°C; 0.666667 h; Inert atmosphere; 2: propargyl alcohol With triethylamine in tetrahydrofuran T=50°C; 2 h; Inert atmosphere;

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 60 °C 2.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 0.67 h / 60 °C / |Inert atmosphere 2.2: 2 h / 50 °C / |Inert atmosphere View Scheme

pyridinium chlorochromate in dichloromethane T=20°C; 4 h; Molecular sieve;