反应条件
1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C
1.2: pH Ca. 3 - 3.5
2.1: N,N-dimethyl acetamide / 1 h / 20 °C
3.1: N,N-dimethyl acetamide / 6 h / 50 °C
4.1: sodium hydroxide / N,N-dimethyl acetamide / 4 h / 50 °C
4.2: 20 °C / pH Ca. 5
View Scheme
参考文献
Kuethe, Jeffrey T.; Childers, Karla G.; Humphrey, Guy R.; Journet, Michel; Peng, Zhihui
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1201 - 1208
